Retinal morphological changes and susceptibility to Age-Related Macular Degeneration
RetourIn a cohort of elderly residents of Bordeaux, researchers from the BPH – LEHA team found how morphological changes of the retina contribute to the susceptibility to Age-related macular degeneration (AMD), the leading cause of vision loss in older adults in France. The results are published in the journal Ophthalmology.
Example of a spectral domain-OCT scan
Using retinal imaging (spectral-domain OCT, see image), we discovered a strong link between the thickening of a specific layer in the retina, known as the retinal pigment epithelium-Bruch’s membrane (RPE-BM) complex and the risk of AMD progression.
In a nutshell, the thicker this complex, the higher the risk of AMD progression. We also found that this thickening was closely tied to genetic risk factors for AMD.
These results highlight the importance of RPE-BM complex thickening in the progression of AMD. Further longitudinal are needed to understand if RPE-BM thickening could be used for clinical managing of AMD.
More information with the article : https://www.aaojournal.org/article/S0161-6420(25)00003-X/fulltext
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