Safe and effective vaccines against COVID-19 were essential in overcoming the pandemic and remain our best tool for protecting citizens.

 

The BPH-SISTM  team and the UMS 54 MART « Methods and Applied Research for Trials » platform are contributing as partners to the European SOLVE Sustainable COVID-19 Vaccination for Long-term Vaccine Immunity and Effectiveness project launched in January 2024.

The aim of this 5-year project, supported by the European Union for almost €9 million, is to challenge the major difficulties  caused  by the arrival of new variants of the SARS-CoV-2 virus, by exploring new vaccine technologies to create more lasting immunity.

 

 

 

 

 

The main objectives and expected results of the Solve project are :

• designing new vaccines to target mutations in the virus,
• setting up trials and clinical studies to assess and understand immune response mechanisms, developing strong, long-lasting protection;
• analysing the large quantities of data generated by trials to predict and improve immunity using data science,
• and finally, improving public acceptance and use of vaccines.

 

 

 

 

 

The BPH-SISTM and MART teams are stakeholders involved in this consortium of 8 renowned public/private institutions in 6 European countries.

 

The SISTM team’s role focuses on the Data Science pillar, where they apply computational methods and statistical analyses to interpret high-throughput data gathered from large cohorts. They will take the challenge of merging multidimensional data from various sources to create holistic models of the immune response.

Their primary aim is to elucidate the factors that impact the durability and quality of immunity induced by various COVID-19 vaccine platforms. The integrative data analysis will identify critical demographic variables, vaccine types, and immune response characteristics that influence long-term vaccine efficacy.

 

These expertises in data science and analysis and clinical trial management in vaccinology is helping to demonstrate the international impact of research conducted at the BPH.

 

New SOLVE website : https://solve-he.eu/

 

More information on Cordis : https://cordis.europa.eu/project/id/101137185